Author + information
- Nicola Ryan,
- Nieves Gonzalo,
- Maria Del Trigo,
- Pilar Jimenez-Quevedo,
- Jorge Gil,
- Juan-Carlos Gomez-Pollo,
- David Neves and
- Javier Escaned
OCT is a high resolution intracoronary imaging technique that allows evaluation of plaque characteristics. FFR assesses the functional significance of stenoses. The relationship between plaque characteristics and FFR is not well established. We aimed to evaluate the differences in plaque characteristics between physiologically significant and non-significant stenosis. A second objective was to evaluate the impact of plaque composition on cardiovascular outcomes.
Ninety-one lesions in 79 patients were evaluated with OCT and FFR; lesions were treated according to functional significance. Plaque characteristics were evaluted with OCT, including detailed analysis of plaque composition (Table 1). Patients were followed up clinically.
Of the 91 lesions assessed, 49 were FFR positive and 42 negative. There were no significant differences in the baseline characteristics of the two groups. Patients were followed up for a median of 65 months (IQR 41-78). Table 1 shows detailed plaque analysis with no significant differences in plaque composition between groups. There was a trend toward increased MI and all-cause revascularisation in the TCFA group, though not statistically significant.
In this population, no differences in plaque characteristics were found in relation to the functional significance of a stenosis. An association between plaque type and events was not seen even though there was a trend toward increased MI and all-cause revascularisation in patients with TCFA.
|Plaque characteristics||Overall||FFR <0.8||FFR >0.8||p value|