Author + information
- Received July 13, 2017
- Revision received August 25, 2017
- Accepted September 13, 2017
- Published online February 5, 2018.
- Wulfran Bougouin, MD, PhDa,b,c,d,
- Florence Dumas, MD, PhDa,b,c,e,
- Nicole Karam, MDa,b,c,d,
- Carole Maupain, MDf,
- Eloi Marijon, MD, PhDa,b,c,d,g,
- Lionel Lamhaut, MD, PhDa,b,d,h,
- Daniel Jost, MDa,b,d,i,
- Guillaume Geri, MD, PhDa,d,
- Frankie Beganton, MSa,b,d,
- Olivier Varenne, MDb,j,
- Christian Spaulding, MD, PhDa,b,c,d,
- Xavier Jouven, MD, PhDa,b,c,d,
- Alain Cariou, MD, PhDa,b,d,k,∗ (, )
- on behalf of the Sudden Death Expertise Center
- aParis Cardiovascular Research Center, INSERM Unit 970, Paris, France
- bUniversité Paris Descartes-Sorbonne Paris Cité, Paris, France
- cCardiology Department, Georges Pompidou European Hospital, AP-HP, Paris, France
- dParis Sudden Death Expertise Center, Paris, France
- eEmergency Department, Cochin-Hotel-Dieu Hospital, APHP, Paris, France
- fCardiology Department, Pitié-Salpétrière Hospital, APHP, Paris, France
- gRescu at Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada
- hIntensive Care Unit and SAMU 75, Necker Enfants-Malades Hospital, Paris, France
- iBrigade de Sapeurs Pompiers de Paris, Paris, France
- jCardiology Department, Cochin Hospital, APHP, Paris, France
- kMedical Intensive Care Unit, AP-HP, Cochin Hospital, Paris, France
- ↵∗Address for correspondence:
Dr. Alain Cariou, Paris Cardiovascular Research Center (INSERM Unit 970), Medical Intensive Care Unit, 27 rue du Faubourg Saint-Jacques, 75014 Paris Cedex 14, France.
Objectives This study sought to assess the relationship between an immediate invasive strategy and survival after an out-of-hospital cardiac arrest (OHCA) of presumed cardiac cause, according to prognosis evaluated on hospital arrival.
Background An immediate coronary angiogram (CAG) may be associated with better outcome after OHCA in neurologically preserved patients but could be futile in other cases.
Methods From May 2011 to May 2015, we collected data for all patients admitted in hospital after OHCA in Paris and its suburbs (France). Risk of in-hospital death was retrospectively calculated using the validated Cardiac Arrest Hospital Prognosis score, which includes age, setting, initial rhythm, durations from collapse to basic life support and from basic life support to return of spontaneous circulation, pH, and epinephrine dose. Independent predictors of survival at discharge (including immediate CAG) were assessed in multivariate logistic regression in each of the 3 pre-defined subgroups of Cardiac Arrest Hospital Prognosis score: low risk (<150 points), medium risk (150 to 200 points), and high risk (>200 points) for in-hospital death.
Results A total of 1,410 patients were included and overall survival rate at hospital discharge was 32%. Distribution in the low-, medium-, and high-risk Cardiac Arrest Hospital Prognosis subgroups was 667 (47%), 469 (33%), and 274 patients (20%), respectively. The rate of early CAG was 86%, 66%, and 47% in the low-, medium-, and high-risk subgroups, respectively (p < 0.001). Early invasive strategy was independently associated with better survival in low-risk patients (odds ratio: 2.3; 95% confidence interval: 1.4 to 3.9; p = 0.001), but not in medium-risk (p = 0.55) and high-risk (p = 0.43) patients. Sensitivity analysis found consistent results.
Conclusions In cardiac arrest patients, our results suggest that investigations regarding early CAG after OHCA should focus on patients with preserved neurological status.
Dr. Varenne has received a grant from Boston Scientific; and lecture fees from Abbott, AstraZeneca, and Servier. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. A complete list of Paris–Sudden Death Expertise Center investigators is found in the Online Appendix.
- Received July 13, 2017.
- Revision received August 25, 2017.
- Accepted September 13, 2017.
- 2018 American College of Cardiology Foundation
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