|Study||Number of Patients||Target Population||Patients Considered for Revascularization Based on Angiography†||Reclassification Rate||Gain/Loss in Patients Undergoing Revascularization Following Pressure Wire||Number of Patients With 1-Year Clinical Outcome|
|Episode 1: R3F||1,075||Mostly stable||488 (45%)||43%||−32 (−6%)||1,075|
|Episode 2: RIPCORD||200||Stable||113 (56%)||27%||−3 (−1%)||0|
|Episode 3: POST-IT||918||Mostly stable||357 (39%)||44.2%||+123 (+34%)‡||918|
|Episode 4: FAMOUS-NSTEMI||176||ACS||158 (90%)||22%||−22 (−12%)||176|
|Episode 5: PRIME-FFR||533∗||ACS||206 ∗(39%)||38%||+42∗ (+24%)||533∗|
|Episode 6: DEFINE-REAL||484||MVD||346 (71%)||45%||−39 (−11%)||0|
|Episode 7: iFR-SWEDEHEART||2,013||Mostly stable|
Including 722 with MVD
|Total||4,866∗||2,744 (56%)||−150 (−5%)||4,182∗|
ACS = acute coronary syndrome(s); DEFINE-REAL = Real-life information for the utilization of instantaneous wave-free ratio™ (iFR®) in assessing coronary stenosis relevance in the multi-vessel disease patient population; FAMOUS-NSTEMI = Fractional flow reserve versus angiography in guiding management to optimize outcomes in non-ST-elevation myocardial infarction; IFR SWEDEHEART = Instantaneous Wave-Free Ratio versus Fractional Flow Reserve A multicenter, prospective, randomized controlled clinical trial based on the Swedish angiography and angioplasty registry (SWEDEHEART) platform; MVD = multivessel disease; POST-IT = Portuguese Study on the Evaluation of FFR-Guided Treatment of Coronary Disease; PRIME-FFR = Insights From the POST-IT (Portuguese Study on the Evaluation of FFR-Guided Treatment of Coronary Disease) and R3F (French FFR Registry) Integrated Multicenter Registries-Implementation of FFR (Fractional Flow Reserve) in Routine Practice; RIPCORD = Does Routine Pressure Wire Assessment Influence Management Strategy at Coronary Angiography for Diagnosis of Chest Pain; R3F = Registre Français de la FFR.
↵∗ Because patients from PRIME-FFR were also part of R3F and POST-IT, they are not included in the total number of patients investigated.
↵† Includes patients initially proposed for percutaneous coronary intervention and/or coronary artery bypass grafting.
↵‡ Includes patients initially proposed to noninvasive ischemia testing, which had a final revascularization decision based on FFR evaluation.