Author + information
- Received November 19, 2017
- Revision received December 26, 2017
- Accepted January 23, 2018
- Published online June 4, 2018.
- David W. Louis, MDa,
- Kevin Kennedy, MSb,
- Fabio V. Lima, MD, MPHa,
- Samir B. Pancholy, MDc,
- J. Dawn Abbott, MDa,
- Paul Gordon, MDa and
- Herbert D. Aronow, MD, MPHa,∗ ()
- aLifespan Cardiovascular Institute, Warren Alpert Medical School of Brown University, Providence, Rhode Island
- bConsulting statistician for the Lifespan Cardiovascular Institute, Providence, Rhode Island
- cWright Center for Graduate Medical Education, Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania
- ↵∗Address for correspondence:
Dr. Herbert D. Aronow, Warren Alpert Medical School of Brown University, The Lifespan Cardiovascular Institute, 593 Eddy Street, RIH APC 730, Providence, Rhode Island 02903.
Objectives This study sought to determine whether higher maximal activated clotting time (ACT) during transradial (TR) percutaneous coronary intervention (PCI) is associated with greater bleeding risk.
Background Higher maximal ACT during transfemoral (TF) PCI has been associated with a greater bleeding risk. It is unclear whether this relationship exists in the setting of TR PCI.
Methods Among 14,637 patients undergoing TR or TF PCI with unfractionated heparin monotherapy, the study related maximal ACT to the risk of major bleeding. In secondary analyses, the study related maximal ACT to composites of in-hospital death, myocardial infarction (MI), or stroke and in-hospital death, MI, or urgent target vessel revascularization. Multivariable logistic regression was employed to compare outcomes in the third with the first and second maximal ACT tertiles.
Results More major bleeding occurred at ACT >290 s versus ≤290 s following TF (7.7% vs. 5.8%; p = 0.006) but not TR PCI (1.7% vs. 2.4%; p = 0.18). After adjustment, major bleeding risk remained significantly higher at ACT >290 s versus ACT ≤290 s among TF (odds ratio: 1.28; 95% confidence interval: 1.02 to 1.62; p = 0.036) but not TR PCI (odds ratio: 0.72; 95% confidence interval: 0.42 to 1.22; p = 0.22). Maximal ACT was not related to the incidence of composite death, MI, or stroke or death, MI, or urgent target vessel revascularization following TF or TR PCI.
Conclusions Higher maximal ACT is associated with a greater risk of major bleeding following TF PCI than TR PCI.
Dr. Pancholy has served as a consultant for Medtronic; has served as a speaker for Terumo; and is owner of VasoInnovations. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received November 19, 2017.
- Revision received December 26, 2017.
- Accepted January 23, 2018.
- 2018 American College of Cardiology Foundation