Author + information
- Hironori Kitabata1,
- Takashi Kubo1,
- Kazuya Mori2,
- Yasunori Yamamoto2,
- Manabu Kashiwagi2,
- Yu Arita2,
- Takashi Tanimoto2 and
- Takashi Akasaka1
In patients ≥80 years of age, the use of second-generation cobalt-chromium everolimus-eluting stents (CoCr-EES) versus bare-metal stents has been shown to reduce myocardial infarction (MI) and target vessel revascularization (TVR) rates, without an increase in bleeding. However, safety and efficacy of CoCr-EES in octogenarians compared with younger populations are less certain.
We aimed to compare the safety and efficacy outcomes between octogenarian and non-octogenarian patients undergoing percutaneous coronary intervention (PCI) with CoCr-EES.
We retrospectively analyzed 186 patients treated with CoCr-EES in our institution from January 2013 to May 2015. Patients were divided into 2 groups: octogenarians (n=54) and non-octogenarians (n=132). The primary end point was a 1-year composite of all-cause death, MI, cerebrovascular accident (CVA), TVR, or major bleeding. Stent thrombosis (ST) was also evaluated.
Radial access was used in 70.4% of octogenarians versus 80.3% of non-octogenarians (p=0.14). Rates of dual antiplatelet therapy at 1 year were 90.7% for octogenarians and 90.9% for non-octogenarians (p=1.00). The primary end point occurred in 14.8% of octogenarians and 11.4% of non-octogenarians (p=0.52). There were no significant differences with respect to the rates of 1-year all-cause death (7.4% vs. 3.8%, p = 0.30), MI (1.9% vs. 1.5%, p=1.00), CVA (1.9% vs. 2.3%, p=0.86), TVR (3.7% vs. 5.3%, p=0.65), and definite/probable ST (1.9% vs. 1.5%, p=1.00) between the 2 groups. Major bleeding was observed in only 1 of octogenarian patients.
According to our series, 1-year safety and efficacy outcomes of CoCr-EES PCI in octogenarians were comparable to those in non-octogenarian populations.