Author + information
- Received February 15, 2017
- Revision received June 5, 2017
- Accepted June 15, 2017
- Published online November 6, 2017.
- Yoichi Takaya, MD∗ (, )
- Teiji Akagi, MD,
- Yasufumi Kijima, MD,
- Koji Nakagawa, MD and
- Hiroshi Ito, MD
- Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan
- ↵∗Address for correspondence:
Dr. Yoichi Takaya, Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Objectives This study aimed to assess the fate of tricuspid regurgitation (TR) after transcatheter atrial septal defect (ASD) closure.
Background Although TR frequently occurs in patients with ASD, the change in TR during long-term follow-up after ASD closure remains unknown.
Methods A total of 419 adult patients who underwent transcatheter ASD closure were enrolled. TR severity was graded by TR jet area on echocardiography.
Results At baseline, 113 patients had severe/moderate TR and 306 patients had mild TR. Among the 113 patients with severe/moderate TR, the TR jet area significantly decreased during a median follow-up of 30 months after the procedure; this decrease was related to the improvement in right ventricular morphology. The severity of TR decreased to mild in 79 (70%) patients. Persistent TR, defined as severe or moderate TR after the procedure, was independently associated with the prevalence of permanent atrial fibrillation. Regarding clinical outcomes, 7 patients with severe/moderate TR and 2 with mild TR were hospitalized because of heart failure. Patients with severe/moderate TR had the worse event-free survival rate than those with mild TR, but more than 90% of them had no cardiovascular events. New York Heart Association functional class and plasma B-type natriuretic peptide levels improved in patients with severe/moderate TR, similar to those with mild TR.
Conclusions Significant TR decreased during the long-term follow-up period after transcatheter ASD closure. Heart failure symptoms improved in patients with severe/moderate TR. Our findings suggest that transcatheter closure alone can be valuable in patients with ASD complicated with TR.
All authors have reported that they have no relationships relevant to the contents of this paper to disclose.
- Received February 15, 2017.
- Revision received June 5, 2017.
- Accepted June 15, 2017.
- 2017 American College of Cardiology Foundation