Author + information
- Received April 10, 2008
- Revision received July 25, 2008
- Accepted August 5, 2008
- Published online October 1, 2008.
- Kazuhiko Nishigaki, MD, PhD,
- Tsutomu Yamazaki, MD, PhD,
- Akira Kitabatake, MD, PhD,
- Tetsu Yamaguchi, MD, PhD,
- Katsuo Kanmatsuse, MD, PhD,
- Itsuo Kodama, MD, PhD,
- Noboru Takekoshi, MD, PhD,
- Hitonobu Tomoike, MD, PhD,
- Masatsugu Hori, MD, PhD,
- Masunori Matsuzaki, MD, PhD,
- Akira Takeshita, MD, PhD,
- Takuro Shimbo, MD, PhD,
- Hisayoshi Fujiwara, MD, PhD⁎ (, )
- JSAP (Japanese Stable Angina Pectoris) Study Investigators
- ↵⁎Reprint requests and correspondence:
Dr. Hisayoshi Fujiwara, Chair of JSAP Study, Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu City, Gifu, 501-1194, Japan
Objectives This study sought to determine whether initial medical therapy (MT) only or percutaneous coronary intervention plus medical therapy (PCI+MT) is better for patients with low-risk stable coronary artery disease (CAD) indicated for intervention in Japan.
Background Several multicenter studies have suggested that in the above patients, an initial management strategy of PCI+MT does not reduce the long-term risk of cardiovascular events more effectively than initial MT only.
Methods We conducted a randomized comparative study (JSAP [Japanese Stable Angina Pectoris] study) in the previously mentioned patients.
Results The patients were randomized to PCI+MT (n = 192) or initial MT only group (n = 192), and the patient characteristics were very similar in the 2 groups. During the 3.3-year follow-up, there was no significant difference in the cumulative death rate between PCI+MT (2.9%) and MT (3.9%). However, the cumulative risk of death plus acute coronary syndrome was significantly smaller in PCI+MT.
Conclusions In stable low-risk CAD, PCI+MT may improve long-term prognosis more effectively than MT.
Sponsorship and oversight of the JSAP Study were provided by a Health and Labour Sciences Research Grant from the Japanese Ministry of Health, Labour, and Welfare and the Japan Heart Foundation (Tokyo, Japan)
- Received April 10, 2008.
- Revision received July 25, 2008.
- Accepted August 5, 2008.
- American College of Cardiology Foundation