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Impact of Vessel Size on Angiographic and Clinical Outcomes of Revascularization With Biolimus-Eluting Stent With Biodegradable Polymer and Sirolimus-Eluting Stent With Durable Polymer

The LEADERS Trial Substudy

Joanna J. Wykrzykowska, MD^_*, Patrick W. Serruys, MD, PhD^_*,_*, Yoshinobu Onuma, MD^_*, Ton de Vries, MA, Gerrit-Anne van Es, PhD, Pawel Buszman, MD, Axel Linke, MD, Thomas Ischinger, MD^||, Volker Klauss, MD^¶, Roberto Corti, MD^#, Franz Eberli, MD, PhD^#,¶¶, William Wijns, MD^_**, Marie-Claude Morice, MD, Carlo di Mario, MD, PhD, Robert Jan van Geuns, MD, PhD^_*, Peter Juni, MD, PhD, Stephan Windecker, MD, PhD^||||

^_* Department of Interventional Cardiology Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands
Cardialysis, Rotterdam, the Netherlands
Medical University of Silesia, Katowice, Poland
Herzzentrum Leipzig, Leipzig, Germany
^|| Department of Cardiology, Hospital Bogenhausen, Munich, Germany
^¶ Department of Cardiology, University Hospital Munich (Innenstadt), Munich, Germany
^# Department of Cardiology, University Hospital, Zurich, Switzerland
^_** Department of Cardiology, Onze Lieve Vrouw Ziekenhuis, Aalst, Belgium
Institut Cardiovasculaire, Paris-Sud, France
Department of Cardiology, Royal Brompton Hospital, London, United Kingdom
Clinical Trials Unit Bern, Bern University Hospital, Bern, Switzerland
^|||| Department of Cardiology, Bern University Hospital, Bern, Switzerland
^¶¶ Triemlispital, Zurich, Switzerland

View larger version (37K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Structure of Biolimus and Scanning Electron Micrograph of the Biolimus Biodegradable Polymer Stent

View larger version (26K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Study Flow Chart

View larger version (17K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Kaplan-Meier Curves for Overall MACE Rate at 1 Year Kaplan-Meier curves for overall major adverse cardiac events (MACE) rate at 1 year. (A) Small vessels; (B) large vessels; (C) mixed vessels; (D) all vessels.

View larger version (16K): [in this window] [in a new window] [Download PPT slide]   Figure 4 Kaplan-Meier Curves for TLR Rates at 1 Year Kaplan-Meier curves for target lesion revascularization (TLR) rates at 1 year. (A) Small vessels; (B) large vessels; (C) mixed vessels (p = 0.05); (D) all vessels.