Effect of Fluvastatin on Progression of Coronary Atherosclerotic Plaque Evaluated by Virtual Histology Intravascular Ultrasound
Kenya Nasu, MD*,*,
Etsuo Tsuchikane, MD, PhD*,
Osamu Katoh, MD*,
Nobuyoshi Tanaka, MD*,
Masashi Kimura, MD*,
Mariko Ehara, MD*,
Yoshihisa Kinoshita, MD*,
Tetsuo Matsubara, MD*,
Hitoshi Matsuo, MD*,
Keiko Asakura, MD*,
Yasushi Asakura, MD*,
Mitsuyasu Terashima, MD*,
Tadateru Takayama, MD ,
Junko Honye, MD,
Atsushi Hirayama, MD,
Satoshi Saito, MD,
Takahiko Suzuki, MD, PhD*
* Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan
Department of Cardiology, Nihon University Itabashi Hospital, Tokyo, Japan
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Figure 1 Correlation Between Change in LDL Cholesterol Level and Change in Volume of Each Plaque Component
Change in fibro-fatty volume was significantly correlated with a change in low-density lipoprotein (LDL) cholesterol level as shown in B (p < 0.0001). There was no significant correlation between changes in volume of the other plaque components and change in LDL cholesterol level as shown in A, C, and D.
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Figure 2 Correlation Between Change in hsCRP Level and Change in Volume of Each Plaque Component
Change in fibro-fatty volume was significantly correlated with a change in high-sensitivity C-reactive protein (hsCRP) level as shown in B (p = 0.006). There was no significant correlation between changes in volume of the other plaque components and change in hsCRP level as shown in A, C, and D.
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Figure 3 Baseline and 1-Year Follow-Up Gray-Scale and Virtual Histology Intravascular Ultrasound Images Are Presented Side by Side
(A) A representative vessel from the fluvastatin group. Volumetric analyses showed the marked increase of fibrous tissue volume and reduction of fibro-fatty volumes. (B) A representative vessel from the control group. Volumes of all plaque components without fibrous tissue increased during the follow-up period.
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