Effects of Statin Treatments on Coronary Plaques Assessed by Volumetric Virtual Histology Intravascular Ultrasound Analysis
Myeong-Ki Hong, MD*,
Duk-Woo Park, MD ,
Cheol-Whan Lee, MD,
Seung-Whan Lee, MD,
Young-Hak Kim, MD,
Duk-Hyun Kang, MD,
Jae-Kwan Song, MD,
Jae-Joong Kim, MD,
Seong-Wook Park, MD,
Seung-Jung Park, MD,*
* Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University College of Medicine, Seoul, Korea
Department of Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
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Figure 1 A Decrease in Necrotic Core Volume After Statin Treatment
Typical example of a decrease in necrotic core volume by serial volumetric virtual histology (VH) intravascular ultrasound (IVUS) analysis is shown. (A) Baseline and (B) 12-month follow-up gray-scale IVUS images. (C) Baseline and (D) 12-month follow-up VH-IVUS images. The amounts of necrotic core components decreased from 2.3 mm2 (47%) baseline to 1.1 mm2 (24%) 12-month follow-up.
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Figure 2 Baseline HDL-Cholesterol Level Versus Necrotic Core Volume
The correlation between baseline high-density lipoprotein (HDL) cholesterol level and change in necrotic core volume is shown (p = 0.030, r = 0.217, 95% confidence interval: –0.293 to –0.015).
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Figure 3 Necrotic Core Volume Versus P&M Volume
The correlation between the change in necrotic core volume and the change in plaque & media (P&M) volume is shown (p = 0.001, r = 0.329, 95% confidence interval: 0.162 to 0.600).
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