No Association of Chromosome 9p21.3 Variation With Clinical and Angiographic Outcomes After Placement of Drug-Eluting Stents
Petra Hoppmann, MD,
Anna Erl, MD,
Serin Türk, MD,
Klaus Tiroch, MD,
Julinda Mehilli, MD,
Albert Schömig, MD,
Adnan Kastrati, MD,
Werner Koch, PhD*
Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany
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Figure 1 Kaplan-Meier Estimates for 3-Year Adverse Event Rates
Kaplan-Meier curves are shown for combined adverse event rates related to (A) rs7865618, (B) rs1537378, (C) rs1333040, and (D) rs1333049 during a 3-year period. Curves in purple are for the patients homozygous for the major alleles, curves in green are for the heterozygous patients, and curves in black are for the patients homozygous for the minor alleles of the respective single nucleotide polymorphism.
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Figure 2 Genes Close to or Overlapping With a Region on Chromosome 9p21.3 Associated With Coronary Heart Disease
A  100 kb region on chromosome 9p21.3 containing multiple single nucleotide polymorphisms strongly associated with coronary heart disease (8–16) is marked with stripes. The positions of the polymorphisms, rs7865618, rs1537378, rs1333040, and rs1333049, addressed in this report are indicated. Loci and orientations (directions of transcription) of genes near and within this sequence and potentially involved in disease mechanisms are shown as arrows. CDKN2A, gene encoding the cyclin-dependent kinase inhibitors p16INK4a and p14ARF; CDKN2B, gene encoding the cyclin-dependent kinase inhibitor p15INK4b; ANRIL, gene for antisense noncoding RNA in the INK4 locus; p15AS, antisense RNA directed against the (sense) RNA for p15INK4b.
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