Pharmacogenetic Testing for Clopidogrel Using the Rapid INFINITI AnalyzerA Dose-Escalation Study
Patrick Gladding, MBChB*, ,*,
Harvey White, MBChB, DSc*,
Jamie Voss, MBChB*,
John Ormiston, MBChB*,
Jim Stewart, MBChB*,
Peter Ruygrok, MD, MBChB*,
Badi Bvaldivia ,
Ruth Baak, PhD,
Catherine White, MBChB*,
Mark Webster, MBChB*
* Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand
AutoGenomics, Carlsbad, California
Theranostics Lab (NZ) Ltd., Auckland, New Zealand
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Figure 2 Platelet Function at Baseline (75 mg) and 7 Days (150 mg)
Platelet function at baseline in patients on 75 mg once daily clopidogrel and after 1 week of 150 mg daily. Variable responses but overall a mean increase in platelet inhibition is demonstrated.
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Figure 3 Platelet Function in CYP2C19*2 Carriers at Baseline and 7 Days
Platelet function at baseline in CYP2C19*2 carriers and after 1 week of 150 mg daily clopidogrel. An improvement in platelet inhibition is seen in most patients.
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Figure 4 Change in Percentage Platelet Inhibition in CYP2C19*2 Carriers
Box plots represent median, range, and 25th and 75th quartiles. See text for discussion of poor metabolizer (PM) and intermediate metabolizer (IM) status.
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Figure 5 Change in Percentage Platelet Inhibition Over 1 Week in Patients on PPI
Increase in platelet inhibition after 1 week of 150 mg daily clopidogrel, in patients taking proton pump inhibitors (PPIs).
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Figure 6 Clopidogrel Response Incorporating Static and Variable Factors
CES = carboxylesterase; CVA = stroke; hPXR = human pregnane X receptor; IL = interleukin; TNF = tumor necrosis factor; T2DM = type II diabetes; wt = weight.
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