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J Am Coll Cardiol Intv, 2009; 2:1083-1091, doi:10.1016/j.jcin.2009.08.016
© 2009 by the American College of Cardiology Foundation
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Enoxaparin Versus Unfractionated Heparin in Elective Percutaneous Coronary Intervention

1-Year Results From the STEEPLE (SafeTy and Efficacy of Enoxaparin in Percutaneous coronary intervention patients, an internationaL randomized Evaluation) Trial

Gilles Montalescot, MD, PhD*,*, Richard Gallo, MD{dagger}, Harvey D. White, MB, ChB, DSc{ddagger}, Marc Cohen, MD§, Ph. Gabriel Steg, MD||, Philip E.G. Aylward, MB, ChB, PhD, Christoph Bode, MD, PhD#, Massimo Chiariello, MD**, Spencer B. King, III, MD{dagger}{dagger}, Robert A. Harrington, MD{ddagger}{ddagger}, Walter J. Desmet, MD§§, Carlos Macaya, MD, PhD||||, Steven R. Steinhubl, MD¶¶,## for the STEEPLE Investigators

* Institut du Cœur, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris, France
{dagger} The Montreal Heart Institute, University of Montreal, Montreal, Canada
{ddagger} Auckland City Hospital, Auckland, New Zealand
§ Division of Cardiology, Newark Beth Israel Medical Center, Newark, New Jersey
|| INSERM U-698, Université Paris 7 and AP-HP, Paris, France
Cardiology Research, Flinders Medical Centre, South Australia, Australia
# Abteilung Innere Medizin III, Universitätsklinikum Freiburg, Freiburg, Germany
** Division of Cardiology, Federico 2nd University, Naples, Italy
{dagger}{dagger} St Joseph's Heart and Vascular Institute, Atlanta, Georgia
{ddagger}{ddagger} Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina
§§ University Hospital Gasthuisberg, Leuven, Belgium
|||| Servicio de Cardiología, Hospital Universitario, Madrid, Spain
¶¶ Geisinger Clinic, Geisinger Center for Health Research, Danville, Pennsylvania
## The Medicines Company, Zurich, Switzerland


Figure 1
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Figure 1 Kaplan-Meier Survival Curves for All-Cause Mortality According to Study Treatment

Kaplan-Meier survival curves for enoxaparin (Enox) 0.50 mg/kg and 0.75 mg/kg, and unfractionated heparin (UFH) treatment groups showing (A) landmark analysis of all-cause mortality starting at day 30 post-randomization; and (B) all-cause mortality from randomization to 1 year.

 

Figure 2
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Figure 2 All-Cause Mortality Rates According to the Occurrence of Initial Ischemic or Bleeding Complications

All-cause mortality rates at 1 year in patients who did, or did not experience the following events: (A) nonfatal myocardial infarction (MI) or urgent target vessel revascularization (UTVR); (B) increased creatine kinase (CK) levels or creatine kinase-myocardial/brain mass (CK-MB) fraction release; and (C) major bleeding. ULNR = upper limit of the normal range.

 

Figure 3
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Figure 3 Risk Factor Analysis for All-Cause Mortality at 1 Year

ASA = aspirin; CI = confidence interval; HR = hazard ratio; PCI = percutaneous coronary intervention; other abbreviations as in Figure 2.

 




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