Prognostic Impact of Periprocedural Bleeding and Myocardial Infarction After Percutaneous Coronary Intervention in Unselected PatientsResults From the EVENT (Evaluation of Drug-Eluting Stents and Ischemic Events) Registry
Jason B. Lindsey, MD*,
Steven P. Marso, MD*,
Michael Pencina, PhD ,
Joshua M. Stolker, MD*,
Kevin F. Kennedy, MS*,
Charanjit Rihal, MD ,
Greg Barsness, MD,
Robert N. Piana, MD ,
Steven L. Goldberg, MD||,
Donald E. Cutlip, MD¶,
Neal S. Kleiman, MD#,
David J. Cohen, MD, MSc*,* on behalf of the EVENT Registry Investigators
* Saint Luke's Mid America Heart Institute, University of Missouri-Kansas City, Kansas City, Missouri
Statistical Consulting Unit, Boston University, Boston, Massachusetts
Mayo Clinic, Rochester, Minnesota
Vanderbilt University Medical Center, Nashville, Tennessee
|| University of Washington Medical Center, Seattle, Washington
¶ Beth Israel Deaconess Medical Center, Boston, Massachusetts
# Methodist DeBakey Heart Center, Houston, Texas
View larger version (20K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 1 Study Flow Diagram
Study flow diagram illustrating the number and reason for exclusion. CK = creatine kinase; STEMI = ST-segment elevation myocardial infarction; ULN = upper limit of normal.
|
|
View larger version (20K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 2 1-Year Mortality Among Patients With and Without Post-PCI Bleeding
Kaplan-Meier curves demonstrating 1-year all-cause mortality among patients with and without (A) post-percutaneous coronary intervention (PCI) bleeding or (B) bleeding, stratified according to the Thrombolysis In Myocardial Infarction major and minor bleeding criteria.
|
|
View larger version (15K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 3 Multivariable-Adjusted HRs for the Association Between Post-PCI Bleeding and 1-Year Mortality
Adjusted hazard ratios (HRs) for the association between post-percutaneous coronary intervention (PCI) bleeding and 1-year mortality. *Model 1: adjusted for sociodemographic factors; Model 2: adjusted for Model 1 covariates + clinical factors; Fully adjusted: adjusted for all Model 2 covariates + angiographic and procedural factors + periprocedural myocardial infarction. See Methods section for full list of model covariates.
|
|
View larger version (11K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 4 1-Year Mortality Among Patients With and Without Periprocedural MI
Kaplan-Meier curves of 1-year post-percutaneous coronary intervention mortality among patients with and without periprocedural myocardial infarction (MI).
|
|
View larger version (14K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 5 Multivariable-Adjusted HRs for the Association Between pMI and 1-Year Mortality
Adjusted hazard ratios (HRs) for the association between periprocedural myocardial infarction (pMI) and 1-year mortality. *Model 1: adjusted for sociodemographic factors; Model 2: adjusted for Model 1 covariates + clinical factors; Fully adjusted: adjusted for all Model 2 covariates + angiographic and procedural factors + post-percutaneous coronary intervention bleeding. See Methods section for full list of model covariates.
|
|
|
