Percutaneous Coronary Intervention Plus Medical Therapy Reduces the Incidence of Acute Coronary Syndrome More Effectively Than Initial Medical Therapy Only Among Patients With Low-Risk Coronary Artery DiseaseA Randomized, Comparative, Multicenter Study
Kazuhiko Nishigaki, MD, PhD,
Tsutomu Yamazaki, MD, PhD,
Akira Kitabatake, MD, PhD,
Tetsu Yamaguchi, MD, PhD,
Katsuo Kanmatsuse, MD, PhD,
Itsuo Kodama, MD, PhD,
Noboru Takekoshi, MD, PhD,
Hitonobu Tomoike, MD, PhD,
Masatsugu Hori, MD, PhD,
Masunori Matsuzaki, MD, PhD,
Akira Takeshita, MD, PhD,
Takuro Shimbo, MD, PhD,
Hisayoshi Fujiwara, MD, PhD* for the JSAP (Japanese Stable Angina Pectoris) Study Investigators
Second Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu City, Gifu, Japan
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Figure 1 Enrollment of the Patients and the Outcomes
Note that additional elective percutaneous coronary intervention (PCI) was significantly lower in the PCI plus medical group than the initial medical therapy only group. *The percentage of repeat revascularization in the PCI plus medical group was significantly lower than that in the initial medical therapy only group (p = 0.001).
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Figure 2 Kaplan-Meier Survival Curves for the Primary End Point
Note that the survival curves free of all causes of death (Death) + acute coronary syndrome (ACS), Death + ACS + cerebrovascular accidents (CVA), and Death + ACS + CVA + Hospitalization (emergency hospitalization) in the PCI plus medical therapy group was shifted significantly upward to that in the initial medical therapy only group, although Death was similar in the 2 groups. *The number of patients in each of the PCI plus medical therapy and initial medical therapy only groups. Abbreviations as in Figure 1.
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Figure 3 Changes in the Severity of Angina Symptoms During the Follow-Up
Note that the severity was significantly lower in the PCI plus medical therapy group than in the initial medical therapy only group. *p < 0.05. **p < 0.01 vs. the PCI plus medical therapy group. #Overall, the interaction between treatment and time was tested in repeated-measurement multivariate analysis of variance for complete cases. After missing observations were imputed using the last observation carried forward method, the p value was <0.0001. Abbreviations as in Figure 1.
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