Long-Term Outcomes in High-Risk Symptomatic Patients With Hypertrophic Cardiomyopathy Undergoing Alcohol Septal Ablation
Deborah H. Kwon, MD*,
Samir R. Kapadia, MD, FACC*,
E. Murat Tuzcu, MD, FACC*,
Carmel M. Halley, MD*,
Eiran Z. Gorodeski, MD, MPH*,
Ronan J. Curtin, MD*,
Maran Thamilarasan, MD, FACC*,
Nicholas G. Smedira, MD, FACC ,
Bruce W. Lytle, MD, FACC,
Harry M. Lever, MD, FACC*,
Milind Y. Desai, MD, FACC*,*
* Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio
Department of Cardiothoracic Surgery, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
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Figure 1 Kaplan-Meier Curves Demonstrating Difference in Long-Term Survival in Alcohol Ablation Group, on the Basis of Age
Patients >65 years of age had worse survival than those younger.
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Figure 2 Univariate Survival Analysis of Patients Undergoing Alcohol Ablation
Only patients who were >65 years of age achieved statistical significance (p < 0.05; other: p > 0.10). CI = confidence interval; LVOT = left ventricular outflow tract; MR = mitral regurgitation; VT = ventricular tachycardia.
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Figure 3 Change in Minnesota Living With Heart Failure Score at 3 Months, Compared With Baseline
All patients had an improvement in the Minnesota Living With Heart Failure score at 3 months’ follow-up.
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Figure 4 Change in Maximal (Resting or Provocable) LVOT Gradient at 3 Months, Compared With Baseline
Vast majority of the patients had a significant reduction in the maximal left ventricular outflow tract (LVOT) gradient at 3-month follow-up.
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Figure 5 Changes in Basal Interventricular Septal Thickness and Mitral Regurgitation
(A) Change in basal interventricular septal thickness at 3 months, compared with baseline. (B) Change in mitral regurgitation at 3 months, compared with baseline.
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