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Upfront Thrombus Aspiration in Primary Coronary Intervention for Patients With ST-Segment Elevation Acute Myocardial Infarction

Report of the VAMPIRE (VAcuuM asPIration thrombus REmoval) Trial

Yuji Ikari, MD, PhD, FACC^_*, Masami Sakurada, MD, Ken Kozuma, MD, PhD, Shigeo Kawano, MD, Takaaki Katsuki, MD, PhD^||, Kazuo Kimura, MD^¶, Takahiko Suzuki, MD^#, Takehiro Yamashita, MD, PhD^_**, Akinori Takizawa, MD, Kazuo Misumi, MD, Hideki Hashimoto, MD, PhD, Takaaki Isshiki, MD, FACC^,_* VAMPIRE Investigators

^_* Department of Cardiology, Tokai University School of Medicine, Isehara, Japan
Department of Cardiology, Tokorozawa Heart Clinic, Tokorozawa, Japan
Department of Cardiology, Teikyo University School of Medicine, Tokyo, Japan
Department of Cardiology, Sakurabashi Watanabe Hospital, Osaka, Japan
^|| Department of Cardiology, Jichi Medical University, Shimotsuke, Japan
^¶ Department of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
^# Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan
^_** Department of Cardiology, Cardiovascular Center Hokkaido Ohno Hospital, Sapporo, Japan
Department of Cardiology, Shizuoka City Hospital, Shizuoka, Japan
Department of Cardiology, Chiba West General Hospital, Matsudo, Japan
Department of Health Economics and Epidemiology Research, University of Tokyo, Tokyo, Japan.

View larger version (52K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Randomization Flow The figure indicates the patient randomization and flow of the VAMPIRE (VAcuuM asPIration thrombus REmoval) study. BNP = brain natriuretic peptide; cTFC = corrected Thrombolysis in Myocardial Infarction frame count; LVG = left ventriculography; PCI = percutaneous coronary intervention; TIMI= Thrombolysis In Myocardial Infarction.

View larger version (16K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Coronary Flow Immediately After the Procedure Figure shows the end point results for the TransVascular Aspiration Catheter (TVAC) group versus non-TVAC group. (A) The primary end point of this study: complication rate of slow flow or no reflow (p = 0.07). (B) The secondary end point: myocardial blush grade (p < 0.001).