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A Novel Filter-Based Distal Embolic Protection Device for Percutaneous Intervention of Saphenous Vein Graft Lesions

Results of the AMEthyst Randomized Controlled Trial

Dean J. Kereiakes, MD, FACC^_*,_*, Mark A. Turco, MD, FACC, Jeffrey Breall, MD, PhD, Naim Z. Farhat, MD, Robert L. Feldman, MD^¶, Brent McLaurin, MD^||, Jeffrey J. Popma, MD, FACC^_**, Laura Mauri, MD, MSc^_**,, Peter Zimetbaum, MD^,, Joseph Massaro, PhD, Donald E. Cutlip, MD^, on behalf of the AMEthyst Study Investigators

^_* The Christ Hospital Heart and Vascular Center and the Lindner Research Center, Cincinnati, Ohio
Center for Cardiac & Vascular Research, Washington Adventist Hospital, Takoma Park, Maryland
Krannert Institute of Cardiology, Indiana University of Medicine, Indianapolis, Indiana
North Ohio Heart Center, Elyria, Ohio
^¶ Munroe Regional Medical Center, Ocala, Florida
^|| Anderson Area Medical Center, Anderson, South Carolina
^_** Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts
Harvard Clinical Research Institute, Boston, Massachusetts
Beth Israel Deaconess Medical Center, Boston, Massachusetts.

View larger version (49K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Interceptor PLUS Coronary Filter System Components of the Interceptor PLUS Coronary Filter System include: (A) actuator handle for filter deployment and closure; (B) low profile (2.7-F) of the undeployed filter on a 0.014-inch wire; and (C) expanded filter with 1,400- to 1,800-µm proximal in-flow openings (large arrow) and 100-µm distal pores (small arrow).

View larger version (90K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Comparison of Filter Open-Pore Areas Scanning electron microscopy of expanded (A) FilterWire EZ and (B) Interceptor PLUS devices. The open-pore area of the Interceptor PLUS exceeds that of the FilterWire EZ (71% vs. 27%, respectively) and results in greater relative flow (60%) measured in vitro.