Head-to-Head Comparison of Coronary Plaque Evaluation Between Multislice Computed Tomography and Intravascular Ultrasound Radiofrequency Data Analysis
Gabija Pundziute, MD*, ,
Joanne D. Schuijf, PhD*,
J. Wouter Jukema, MD, PhD*,
Isabel Decramer, MSc ,
Giovanna Sarno, MD,
Piet K. Vanhoenacker, MD,
Johannes H.C. Reiber, PhD ,
Martin J. Schalij, MD, PhD*,
William Wijns, MD, PhD,
Jeroen J. Bax, MD, PhD*,*
* Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands
Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
Department of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania
Cardiovascular Center, OLV Hospital, Aalst, Belgium.
View larger version (57K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 1 Plaque Characterization by VH IVUS
(A) A traditional grayscale intravascular ultrasound (IVUS) cross-sectional image of coronary plaque. (B) Corresponding image using virtual histology IVUS (VH IVUS), depicting different color-coded tissues based on spectral analysis of the radiofrequency ultrasound signals. The components are indicated by dark green for fibrotic tissue; light green for fibro-fatty tissue; red for necrotic core; white for dense calcium.
|
|
View larger version (72K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 2 Example of Plaque Composition on MSCT and VH IVUS
(A) Noncalcified plaque with corresponding transversal section. On VH IVUS, plaque containing predominantly fibrous and fibro-fatty tissues is demonstrated. (B) Mixed plaque with corresponding transversal section, showing the features of thin-cap fibroatheroma on VH IVUS. (C) Calcified plaque with corresponding transversal section demonstrating circular pattern of calcium accumulation. The corresponding VH IVUS image confirms the circular deposition of dense calcium in the plaque. Noncalcified tissue located behind the calcium is depicted, which is not visible on the MSCT images due to the partial volume effect of extensive calcifications. MSCT = multislice computed tomography; other abbreviation as in Figure 1.
|
|
View larger version (12K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 3 Correlation of Agatston Score With Volume of Dense Calcium
Correlation of the Agatston coronary calcium score (HU) on MSCT and the volume of dense calcium (mm3) on VH IVUS in the total of those coronary segments in which VH IVUS examination was performed. HU = Hounsfield units; other abbreviations as in Figures 1 and 2.
|
|
View larger version (14K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 4 Differences in Coronary Plaque Composition on VH IVUS Between Noncalcified, Mixed, and Calcified Plaques on MSCT
Significantly more fibrotic and fibro-fatty tissues were demonstrated in noncalcified plaques as compared with calcified plaques (A, B). Mixed and calcified plaques contained significantly more necrotic core tissue and dense calcium on VH IVUS as compared with noncalcified plaques (C, D). Abbreviations as in Figures 1 and 2.
|
|
View larger version (8K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 5 Prevalence of TCFAs in the 3 Types of Plaques on MSCT
Thin-cap fibroatheromas (TCFAs) were significantly more prevalent in mixed plaques as compared with noncalcified and calcified plaques. Other abbreviation as in Figure 2.
|
|
|
