Evaluation of a Novel Slow-Release Paclitaxel-Eluting Stent With a Bioabsorbable Polymeric Surface Coating
Refat Jabara, MD*,*,
Nicolas Chronos, MD, FACC*,
Damian Conway, MSc ,1,
Warner Molema, PhD,1,
Keith Robinson, PhD, FACC*
* Saint Joseph’s Cardiovascular Research Institute/Saint Joseph’s Hospital of Atlanta, Georgia
DISA Vascular Ltd., Cape Town, South Africa.
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Figure 1 Elution Profile of Paclitaxel From Bioabsorbable Coating
Elution of paclitaxel in saline at 37°C from bioabsorbable coating on 5 samples of cobalt chromium stents. A mild burst-release for 20 days is followed by more gradual release; a subsequent increase in release rate after 50 days subsides as >90% of drug has eluted.
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Figure 2 Angiographic Percent Diameter Stenosis at 1 and 3 Months
Angiographic percent diameter stenosis at 1 and 3 months’ follow-up in stented pig coronary arteries according to treatment group. BMS = bare-metal stent.
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Figure 3 Low-Magnification Microscopic Images of Sections From 1- and 3-Month Samples
Low-magnification microscopic images of Movat-stained sections from 1- and 3-month samples demonstrating comparative overall vessel morphologies, with thinner neointima for the paclitaxel-eluting stent at 1 month. BMS = bare-metal stent.
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Figure 4 High-Magnification Microscopic Images of Sections From 1- and 3-Month Samples
High-magnification microscopic images of hematoxylin and eosin-stained sections from pig coronary arteries fixed 1 and 3 months after stent implant. Note thin neointima with some residual fibrin deposits, but no media necrosis for the paclitaxel-eluting stent at 1 month and well-healed arterial wall response for this stent at 3 months. BMS = bare-metal stent.
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Figure 5 Intimal Thickness of Tissue Overlying Stent Struts at 1 and 3 Months
Intimal thickness of tissue overlying the stent struts, measured from histologic sections of porcine coronary arteries harvested at 1 and 3 months after stent implant, according to treatment group. BMS = bare-metal stent.
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Figure 6 Histological Percent Area Stenosis at 1 and 3 Months
Proportion of area within stent occupied by neointimal tissue (% stenosis) measured from histologic sections of porcine coronary arteries harvested at 1 and 3 months after stent implant, according to treatment group. BMS = bare-metal stent.
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