Six-Month Comparison of Coronary Endothelial Dysfunction Associated With Sirolimus-Eluting Stent Versus Paclitaxel-Eluting Stent
Jin Won Kim, MD, PhD,
Soon Yong Suh, MD, PhD,
Cheol Ung Choi, MD,
Jin Oh Na, MD,
Eung Ju Kim, MD, PhD,
Seung-Woon Rha, MD, PhD,
Chang Gyu Park, MD, PhD,
Hong Seog Seo, MD, PhD,
Dong Joo Oh, MD, PhD*
Cardiovascular Center, Korea University, Guro Hospital, Seoul, Republic of Korea.
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Figure 1 Examples of Coronary Angiogram With Endothelial Function Test at 6 Months After Stent Implantation
Coronary angiogram showed a marked vasoconstriction to incremental acetylcholine infusion, in particular in the segment distal to sirolimus-eluting stent (SES) (upper panel) and paclitaxel-eluting stent (PES) (middle panel) compared with those of bare-metal stent (BMS) (lower panel) or midsegments of the left circumflex artery as a reference nonstented artery.
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Figure 2 Comparative Analysis of Mean Percent Changes of Coronary Diameter in Response to Incremental Ach and Nitrate Infusion at 6 Months After Stent Implantation
Sites proximal and distal to DES showed a greater vasoconstriction in the DES group than in the BMS group or corresponding segments of the left circumflex artery (LCX) as a reference artery. Mean coronary diameter changes were similar in the SES and PES groups. Ach = acetylcholine; LAD = left anterior descending coronary artery; other abbreviations as in Figure 1.
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Figure 3 Comparative Analysis of Mean Percent Changes of Coronary Diameter in Response to Maximal Ach at 6 Months After Stent Implantation
Significant vasoconstrictions to maximal Ach infusion were observed in the segments distal to DES compared with those of BMS. Mean coronary diameter changes were similar between SES and PES. Changes in mean luminal diameter in response to Ach were greater at distal than proximal sites to stents in both the SES and PES groups. Open bars = SES; solid bars = PES; hatched bars = BMS. Abbreviations as in Figures 1 and 2.
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