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The Pre-Clinical Animal Model in the Translational Research of Interventional Cardiology

Yoriyasu Suzuki, MD^_*,, Alan C. Yeung, MD^_*, Fumiaki Ikeno, MD^_*,_*

^_* Division of Cardiovascular Medicine, School of Medicine, Stanford University, Stanford, California
Department of Cardiovascular Medicine, Nagoya Heart Center, Aichi, Japan

^_* Reprint requests and correspondence: Dr. Fumiaki Ikeno, Stanford University, Division of Cardiovascular Medicine, 300 Pasteur Drive, Falk CVRB007, Stanford, California 94305 (Email: fikeno{at}cvmed.stanford.edu).

Scientific discoveries for improvement of human health must be translated into practical applications. Such discoveries typically begin at "the bench" with basic research, then progress to the clinical level. In particular, in the field of interventional cardiology, percutaneous cardiovascular intervention has rapidly evolved from an experimental procedure to a therapeutic clinical setting. Pre-clinical studies using animal models play a very important role in the evaluation of efficacy and safety of new medical devices before their use in human clinical studies. This review provides an overview of the emerging role, results of pre-clinical studies and development, and evaluation of animal models for percutaneous cardiovascular intervention technologies for patients with symptomatic cardiovascular disease.

Key Words: pre-clinical study • animal model • cardiovascular intervention

Abbreviations and Acronyms   AS = aortic stenosis   CTO = chronic total occlusion   DES = drug-eluting stent(s)   LAA = left arterial appendage   MI = myocardial infarction   MR = mitral regurgitation   PES = paclitaxel-eluting stent(s)   PFO = patent foramen ovale   SES = sirolimus-eluting stent(s)   VHD = valvular heart disease

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